“A new world”—After going on a rampage with her partner-in-crime The Joker, Harley Quinn is sent straight to Belle Reve Penitentiary. Now in prison, Harley is selected by Amanda Waller to join her operative Peacemaker and other misfit Super-Villains including Deadshot and Clayface on a top-secret mission in another world!

Harley Quinn, Deadshot, Peacemaker, Clayface, and King Shark find themselves in a new world of swords and sorcery, known as an “ISEKAI.” This Suicide Squad wake up in an entirely different kind of jail where they meet Rick Flag, an agent of A.R.G.U.S. But what’s he doing there? And why exactly were they sent to this ISEKAI? They’ll have to work together and escape to find out!

Harley Quinn and the Suicide Squad strike a deal with Queen Aldora of the Kingdom to deactivate the bombs in their necks. The catch? “Conquer the hostile Imperial Army.” So off they go to a treacherous battlefield, where beasts go berserk and magical attacks fly every which way! While the Squad scope out the scene, Deadshot drops a bombshell: The enemy commander is an old buddy of his!

In the ISEKAI, the war between the Kingdom and the Empire has been raging for decades. Hoping to finally end the carnage, Princess Fione of the Kingdom enlists Harley and her team’s help. But the Empire’s attacks, led by Deadshot’s old buddy Ratcatcher, are relentless. So, the Squad come up with a scheme to take him down. Let the rat hunt begin!

Taking on Ratcatcher’s army of beasts turns out to be a piece of cake for the Suicide Squad, and they have no problems resetting the bombs around their necks. This calls for a celebration! Or not... ’cause Deadshot’s out of bullets.

Harley and the Suicide Squad triumphantly return from dragon-slaying when they find a blazing fortress and a heartbreaking defeat.

To stop the Suicide Squad from resetting their bombs, Thinker has his elf army build a fortress near the gate. But who decides to drop by? Katana! Looking to settle their scores once and for all, Harley and the Squad cook up a mean plan to serve up some sweet revenge!